Lung Cancer Oncology and Hematology
At Alaska Oncology and Hematology, we provide evidence-based care for individuals diagnosed with lung cancer. Our team uses advanced diagnostic tools and the latest therapies to help patients make informed treatment decisions and access personalized care.
What is Lung Cancer?
Lung cancer begins when abnormal cells grow uncontrollably in the lungs. These cells often start in the bronchial tubes, which carry air in and out of the lungs. Over time, the cells can form tumors and may spread to nearby tissues or distant organs.
There are two primary types of lung cancer:
Diagnostic Testing and Staging
An accurate diagnosis is the foundation of effective lung cancer treatment. After identifying the type of cancer, our physicians use a series of tests to determine how far it has spread (the "stage"). Staging helps guide treatment options and assess prognosis.
Common Diagnostic Procedures
Biopsy Techniques
A tissue sample is collected for microscopic evaluation. This may involve:
- Bronchoscopy
- Fine-needle aspiration
- Thoracentesis
- Sputum cytology
- Thoracotomy
Imaging and Staging Tests
- CT Scan (Computed Tomography): Creates detailed cross-sectional images of the lungs and chest
- PET Scan (Positron Emission Tomography): Detects cancer activity by measuring cellular sugar metabolism
- MRI (Magnetic Resonance Imaging): Useful for identifying cancer spread to the brain or spine
Bone Scan: Checks for metastasis to the bones - Mediastinoscopy: A surgical procedure to examine and biopsy lymph nodes in the chest
Each test plays a role in determining the cancer stage, from localized tumors to distant metastases in the lymph nodes, bones, or brain.
Personalized Cancer Treatment Based on Genetic Markers
Thanks to advances in cancer genetics, many lung cancer treatments today are tailored to the tumor’s specific molecular profile. Our team tests tumors for key genetic changes (mutations or fusions) to guide the use of targeted therapies. Targeted therapy options include:
EGFR Mutations (Exon 19 deletion, L858R, Exon 20 insertions)
First-line therapy:
- Osimertinib (Tagrisso®) is the standard for patients with common EGFR mutations. It is also effective in treating brain metastases
For rare EGFR mutations (Exon 20 insertions):
- Amivantamab (Rybrevant®) and Mobocertinib (Exkivity®) are FDA-approved options
- Sunvozertinib (Zegfrovy™): Recently approved for patients who progressed after platinum chemotherapy
ALK Rearrangements
Lorbrena® (lorlatinib): Now preferred for patients with ALK-positive NSCLC. Clinical studies show it reduces progression and prevents brain metastases more effectively than earlier therapies.
Immunotherapy and Chemo-Immunotherapy Combinations
Immunotherapy plays a growing role in the treatment of lung cancer by helping the immune system recognize and attack cancer cells.
Durvalumab (Imfinzi®):
- Approved as a maintenance therapy in stage III NSCLC following chemoradiation
- Recently approved as both neoadjuvant and adjuvant therapy in early-stage NSCLC when combined with chemotherapy
- Also approved for limited-stage SCLC in patients who respond to chemoradiation
These therapies may help reduce recurrence and extend survival in eligible patients.
Lung Cancer in Non-Smokers
While smoking remains the leading cause of lung cancer, up to 20% of cases occur in people who have never smoked.
These cases are often linked to factors such as:
Why Choose Alaska Oncology and Hematology?
When you choose Alaska Oncology and Hematology, LLC for your cancer care, you can expect compassionate and expert care from a team of dedicated professionals.
Our Anchorage clinic provides:
We’re here to support you and your loved ones through every stage of your lung cancer care.
Ready to Talk? We Are Here to Help!
We believe in direct, personal interaction. If you have questions or need to speak with our compassionate team, please call us directly.
STEP 1.
Your First Connection
Please call us; our team is here to offer a listening ear and clear direction for starting your care.
STEP 2.
Guidance for Your Visit
We'll help you prepare for your first appointment by explaining what to bring and what to expect.
STEP 3.
Personalized Options
Our experts will provide clear, understandable information about your condition and work with you to establish your best path forward.